Tag archives: Accurate genetic testing

Paw Print Genetics Launches 15 New Tests

Paw Print Genetics Launches 15 New Tests

Paw Print Genetics is excited to tell you about 15 new tests that were just launched!  Among these new tests are three new trait tests that cause light colored dogs in various breeds. These new traits are sable in Cocker spaniels, white in Alaskan and Siberian huskies, and cream in Australian cattle dogs. What’s super interesting is that these new tests all involved DNA changes in the E locus.  Most are already familiar with the E (extension) locus, as DNA changes or variation in the MC1R gene inhibits the production of the black pigment, eumelanin, and allows the yellow/red pigment to show (phaeomelanin) and causes the coat color to be light, such as apricot in poodles, yellow in Labradors, and red in Irish Setters.  For the specific breeds mentioned above, you can now test specifically for the Eh variation found in some sable Cocker spaniels, or the e2 variation found in cream colored Australian Cattle dogs, or the e3 variation found in Alaskan and Siberian huskies. For all other breeds, you can just continue to order the common E locus variant to find out if your dog carries for yellow. Remember, white/yellow/red ...

National DNA Day 2021

National DNA Day 2021
DNA Day

I founded this company in 2012 with a single vision, to raise the bar regarding canine genetic testing. Since then, Paw Print Genetics (PPG) has tested more than 200,000 dogs and has provided the most comprehensive menu of tests for inherited diseases and traits across more than 350 breeds of dog. We have helped more than 34,000 customers gain access to genetic knowledge to help them improve their breeding program.

Today is National DNA Day – the day we celebrate the successes of the human genome project. The human genome was completed in 2003 and this opened the door to the sequencing of other animal genomes. With knowledge of the dog genome, which was published in 2005, researchers are now able to identify the DNA changes (called mutations or variants) that contribute to hundreds of traits and diseases in dogs.  Once these variants have been identified, we can use this knowledge to develop tests to identify these DNA changes in your dogs.

The unraveling of the dog genome has not only allowed discoveries of single gene mutations but has offered the opportunity to identify and better understand the complexities that exist for some traits and diseases. No ...

Paw Print Genetics Launches 46 New Tests for Dogs

Paw Print Genetics Launches 46 New Tests for Dogs

Paw Print Genetics has launched 44 new inherited disease tests and two new trait tests for various breeds.  With nearly 300 different tests for more than 350 breeds of dog, Paw Print Genetics (PPG) continues to be the leader in providing genetic tests for dogs.  Here are some of the new tests being offered.  You can find these new tests for your breed under the category “Additional Disease Tests” on your breed-specific page on our website.

New Trait Tests

PPG has launched Saddle Tan (As locus) and Intensity (I locus) as part of their large number of coat colors and traits offered for various breeds.  Both of these genetic loci modify a dog’s coat color based on their genotypes at other coat color genes. For Saddle Tan, the variation in the RALY gene will modify a dog’s coat presentation only if the dog also has tan points (kyky at the K locus and at/at or at/a at the A locus).  Sometimes called creeping tan, a dog with one or two copies of the As variant and tan points may show a ‘shrinking’ dark saddle across ...

Happy, Happy New Year from Paw Print Genetics

Happy, Happy New Year from Paw Print Genetics

If you are like me, 2021 is a welcomed sight. As you all experienced, 2020 was full of challenges related to COVID-19. At Paw Print Genetics, some of us have been working from home since March and really miss being able to get together with our colleagues. The laboratory needed to go to different shifts to allow for social distancing, which really put a strain on our turn-around times. We have experienced delays in getting laboratory reagents that allow us to do our testing, as they are being used by other laboratories for COVID testing, and the US Postal Service has been struggling even before the holidays to deliver our kits and your samples in a timely manner.

Even with these challenges, I have kept track of what I like to call the COVID silver linings. First, in Washington State, veterinary services were deemed essential business so although many restaurants and gyms were forced to close, Paw Print Genetics (PPG) remained open. This meant that we were able to serve our customers and keep our staff employed. Even with social distancing and shift work, we were able to meet our published turnaround times for more than 90% of cases! In ...

At Your Service-ALWAYS!

At Your Service-ALWAYS!

Have you ever wondered why we chose AskUs@pawprintgenetics.com to be our contact email address? In addition to offering the highest accuracy in the industry, at Paw Print Genetics, customer service is At Your Service! We want you to ask questions prior to ordering or after receiving your results because we know that genetic testing can sometimes be confusing.

We consider our customers to be part of our family and treat them as such. When a customer is in need of help when placing an order or trying to understand their results, our expert staff is here, ready to help. You can always count on us to respond to your emails or answer your phone calls, even on weekends and holidays! That is because we understand that your dog's results are important to you, and you are important to us. There is no such thing as too small of a question.

Our one-of-a-kind client services staff is here to help by answering your email or phone call, helping to understand our ordering process, or even placing your order.  Our team members, along with our expert geneticists and veterinarians, are pleased to help you. No excuses, no complaints, just ...

Paw Print Genetics Launches New Trait Tests

Paw Print Genetics Launches New Trait Tests

Paw Print Genetics is excited to announce that it has launched six new trait tests for coat color (Cocoa, ba allele of the B Locus, d2 allele of D Locus), coat length (Lh2, Lh4) and ‘weak’ furnishings (Fw allele).  These tests compliment the other coat color and trait tests that PPG already offers and shows our dedication to providing the largest menu of genetic tests for dogs. The following tests can be ordered as individual tests or are now incorporated into the previously offered test.  It is important to order only those tests that are applicable for your breed, so be sure to notice the breeds that can have this mutation, located in the parentheses in the name of the test.  If you are unsure about ordering, please contact us as we are always happy to help you understand the usefulness of the tests that we offer.

Coat Length and Cocoa Coat Color for French Bulldogs

Prior to the discovery of the Cocoa mutation, many French Bulldogs had an untestable form of brown. Thanks to an international group of researchers, the DNA change (variant) responsible for the Cocoa coat color was identified. The ...

Paw Print Genetics Launches Six New, Highly Anticipated Disease Tests

Paw Print Genetics Launches Six New, Highly Anticipated Disease Tests

Paw Print Genetics is excited to announce that it has launched six new, very desired disease tests.  These tests compliment the breed-specific assays that PPG already offers and shows our dedication to providing the largest menu of genetic tests for dogs. The following tests can be ordered as individual tests or may be found as part of one of our breed-specific panels. The breed-specific panels represent the most common and/or severe conditions in your breed and these tests should be considered for any breeding dog.

 

Acral Mutilation Syndrome

Acral Mutilation Syndrome, or AMS, is a neurologic disease affecting Cocker Spaniels, English Cocker Spaniels, English Spring Spaniels, French Spaniels, German Shorthaired Pointers, Old English Sheepdogs and the Pointer. This inherited disease can present around 4 months of age with insensitivity to pain in the lower limbs, repetitive licking and biting of the paws, which eventually can result in self-mutilation. Because affected dogs are unable to feel pain in their feet, they will continue to walk without obvious discomfort. This is an autosomal recessive condition that requires two copies of the mutation to be affected. Screening for carriers will allow breeders to avoid producing puppies with this condition.

Craniomandibular ...

New Year - New Swabs!

New Year - New Swabs!

   At Paw Print Genetics, quality and accuracy are at the heart of everything we do. When it comes to the sample collection on your dog that is used to extract DNA, we continue to hold ourselves to this standard. We have recently changed our cheek cell collection method to a new preferred swab. We believe that this new swab will not only allow us to achieve higher quality DNA from your dog, but it will also make your life more convenient. You may notice these swabs have a few differences…

1. One swab does the job

This new swabbing method will now only involve swabbing your dog’s cheek one time, rather than 3 separate times with different swabs. By using this single swab, we are now able to collect more than enough cells to get the DNA that we need.To collect enough cells, be sure to swab your dog for a slow count of 30. This is super important given that you only get once chance, with one swab, to get enough sample for us. It is our goal is that using a single swab will make the swabbing process simple and easy!

 

2. New look & ...

The Complexities of Genetic Testing and Counseling: Accuracy, Penetrance and Validity, Oh My!

The Complexities of Genetic Testing and Counseling: Accuracy, Penetrance and Validity, Oh My!
Photo showing the diversity of coat colors and patterns within the Australian Shepherd.

As a laboratory that works directly with breeders and dog owners, Paw Print Genetics (PPG) is often asked to reassure the customer that our tests accurately determine whether a dog will get a disease.  The customer is actually asking a couple of different questions; one involving the accuracy of the test itself and one regarding the clinical validity of the test. It is important to understand the questions being asked so that the answers make sense.

The first question being asked is: Does the test perform accurately to determine if a dog is normal/clear, a carrier of one copy of the mutation or at risk, having two copies of the mutation. At PPG, our tests are extensively validated and must show 99.9% specificity and sensitivity before being available for ordering. Sensitivity is defined as the proportion of samples with a known mutation that are correctly classified/identified as carrier or at risk by their genotypes. Specificity is defined as the proportion of samples with no known mutation that are correctly classified/identified with the wildtype (normal) genotype for the disease.  This all refers to whether the test result accurately reflects the true genotype of the individual. At ...

Happy New Year, from the CEO of Paw Print Genetics

Happy New Year, from the CEO of Paw Print Genetics

As one year closes and we begin a new, I like to take this time to reflect on the accomplishments of Paw Print Genetics (PPG).  It still amazes me that in such a short time (PPG was founded in 2012), we have become the most trusted laboratory in the industry.  Even if we didn’t do the testing, breeders come to us for advice and help in figuring out the sometimes complex nature of genetic testing results.  Perhaps this is because we are so accessible. PPG employs PhD geneticists and licensed veterinarians who are on-staff and in our offices, available by phone for consultation about your breeding program, a particular dog that needs testing, or a specific result.  Providing genetic counseling and a helpful ear is so important for assisting breeders in navigating the ever-changing world of canine genetics.

As in previous years, PPG had many accomplishments this year. Only a few are highlighted in the following paragraphs. For me, our biggest accomplishment is how fast we continue to grow and the number of new breeders who tried us for the first time this past year.  These new customers are finding us mostly from you – our current ...