Blog Archives for the year 2020

Pembroke Welsh Corgi Early Onset Risk Modifier

Pembroke Welsh Corgi  Early Onset Risk Modifier

Degenerative myelopathy (DM) is a chronic, progressive neurologic condition that typically develops in the latter third of a dog’s life. DM starts in the central portion of the spinal cord then gradually progresses to involve all spinal cord segments. 1 Although DM is unique to the dog, it is a natural-occurring model of human amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease.3,4 In dogs, the common form of DM results from a DNA change (mutation) in the SOD1 gene. This is a recessive condition, meaning that dogs with two copies of the mutation are at risk for developing DM. For most affected dogs this condition develops late in life, however a change in the DNA at a different gene than the SOD1 gene has been identified in some dogs that modifies the risk for DM in the Pembroke Welsh corgi. In dogs that have two copies of the at-risk DM mutation and have one or two copies of a mutation found in the SP110 gene, will reduce the age of onset for DM.   

Typical DM presents with dysfunctional and abnormal movements of the pelvic limbs around 8 years of age or later. Dogs may ...

At Your Service-ALWAYS!

At Your Service-ALWAYS!

Have you ever wondered why we chose AskUs@pawprintgenetics.com to be our contact email address? In addition to offering the highest accuracy in the industry, at Paw Print Genetics, customer service is At Your Service! We want you to ask questions prior to ordering or after receiving your results because we know that genetic testing can sometimes be confusing.

We consider our customers to be part of our family and treat them as such. When a customer is in need of help when placing an order or trying to understand their results, our expert staff is here, ready to help. You can always count on us to respond to your emails or answer your phone calls, even on weekends and holidays! That is because we understand that your dog's results are important to you, and you are important to us. There is no such thing as too small of a question.

Our one-of-a-kind client services staff is here to help by answering your email or phone call, helping to understand our ordering process, or even placing your order.  Our team members, along with our expert geneticists and veterinarians, are pleased to help you. No excuses, no complaints, just ...

Paw Print Genetics Launches New Trait Tests

Paw Print Genetics Launches New Trait Tests

Paw Print Genetics is excited to announce that it has launched six new trait tests for coat color (Cocoa, ba allele of the B Locus, d2 allele of D Locus), coat length (Lh2, Lh4) and ‘weak’ furnishings (Fw allele).  These tests compliment the other coat color and trait tests that PPG already offers and shows our dedication to providing the largest menu of genetic tests for dogs. The following tests can be ordered as individual tests or are now incorporated into the previously offered test.  It is important to order only those tests that are applicable for your breed, so be sure to notice the breeds that can have this mutation, located in the parentheses in the name of the test.  If you are unsure about ordering, please contact us as we are always happy to help you understand the usefulness of the tests that we offer.

Coat Length and Cocoa Coat Color for French Bulldogs

Prior to the discovery of the Cocoa mutation, many French Bulldogs had an untestable form of brown. Thanks to an international group of researchers, the DNA change (variant) responsible for the Cocoa coat color was identified. The ...

Tissue Management Prior to Genetic Testing

Tissue Management Prior to Genetic Testing

Nothing brightens the schedule like seeing an 11:20am slot given to Mrs. Doe who is bringing in a three-day old litter for assessment, tails and dewclaws.  The whole clinic reminds you all morning that puppies are coming in.  Then the magic hour arrives and in comes Mrs. Doe with a laundry basket covered in a towel that is making a surprising level of grunts and squeals.  Wow! Thirteen little fuzzballs in varied states of activity from litter-surfing to dreamless slumber that makes you a little jealous.  You go through the exam; each one is fully formed with no gross congenital defects.  While prepping your tools for dewclaw removal and tail docking, Mrs. Doe asks that you save the remnants so she can have the litter tested with Paw Print Genetics for known disease-causing mutations in this breed.  Hmmm, what does this entail?

Typically, we recommend to clients who choose to submit cheek swabs to wait until they begin weening the pups off mom. This allows them to separate the puppies from their mother to reduce possible contamination by the mother’s milk that may remain in the puppies’ mouths.  Given that testing takes ...

Canine Halloween Hazards

Canine Halloween Hazards

The leaves are falling and the pumpkins are reaching their proper jack ‘o lantern size. Soon children everywhere will be dining on a steady diet of Halloween candy while many of us adults relive our youth by taking full advantage of the one day every year we can pretend to be someone (or something) else. Though many dogs also enjoy the excitement that Halloween brings, this time of year can present additional hazards and stressors for our canine friends.

 

Alcohol and Junk Food

Although Halloween parties in 2020 are likely to be much different than in years past, our opportunistic dogs are still likely to find themselves around more potentially dangerous food and drink than is typical in their daily lives. A cocktail placed at dog height or a single plate of carelessly placed food have been known to ruin more than one celebratory day.

Alcoholic beverages are a particular concern for dogs during holidays and celebrations. Dogs under the influence of alcohol tend to suffer the same consequences as their overindulgent human counterparts including drowsiness, vomiting, lack of coordination, and slow reflexes. Dogs consuming toxic levels of alcohol may experience depression, breathing and heart rate abnormalities, collapse, low ...

Fall Safety for You and Your Pup

Fall Safety for You and Your Pup

Fall brings some wonderful changes; brisk evening walks with your dog, autumn decorations, curling up on the couch to watch your favorite Halloween flicks to name a few. With the changing of the seasons comes some notable adjustments for your dog too. Below are a few things to help you and your dog prepare for the upcoming autumn season.

Keep an Eye Out for Wildlife

Be extra vigilant this time of year of your dog’s off leash whereabouts. If you live in a more rural area where wildlife is prominent, it may be second nature to keep your eyes peeled for deer, moose, coyotes or even bear. Don’t forget about the smaller animals like porcupine and skunks, all very busy with their winter preparations. These animals could pose unwanted threats to your canine.

Cooler Temperatures

Colder temperatures and shorter days often mean less time spent outside, which could decrease the amount of exercise your dog is getting. This could be especially perilous on older dogs with arthritis. Protexin Veterinary recommends short and consistent exercise for arthritic dogs, if possible, such as shorter walks multiple times a day rather than long winter walks. Additionally, moist heat therapy can decrease pain and ...

Feline Genetic Health Screening with the CatScan- Benefits for Veterinary Practice

Feline Genetic Health Screening with the CatScan- Benefits for Veterinary Practice

The popularity of genetic health testing in domestic animals is rapidly increasing for a variety of different applications. Although genetic testing of dogs has been more widely recognized by the public than similar testing in cats, advancements in genetic testing are also becoming increasingly popular among those that have a special feline in their life. In order to address the genetic health concerns of our cat-loving friends and their wonderful felines, the team at Paw Print Genetics has developed the CatScan, a powerful genetic screening tool for inherited diseases and traits. Aside from its important use by feline breeders to make informed breeding decisions and to prevent the production of kittens with certain inherited diseases, the CatScan also has powerful applications in clinical veterinary medicine especially in cases where testing is performed early in a cat’s life or when the cat’s pedigree is unknown.  

Early Screening for Greatest Impact

From a technical perspective, the CatScan can be performed using cheek swabs from kittens of any age as long as it is possible to prevent contamination of their DNA sample with DNA from other cats or mother’s milk. However, testing kittens early (around the beginning of weaning) is a common ...

Stop, Drop & Roll: Keep Your Pets Safe

Stop, Drop & Roll: Keep Your Pets Safe

With wildfire season upon us, it is important to prepare and understand what actions to take in the case of an evacuation, specifically with your pets. Fires can be unpredictable and can be destructive within a matter of minutes. Whether you live in an area that is susceptible to wildfires or not, taking these steps to prepare for an emergency can go a long way in the time of a disaster.

Paw Print Genetics Adds New Canine Genetic Disease Tests to Ever-Expanding Offerings

Paw Print Genetics Adds New Canine Genetic Disease Tests to Ever-Expanding Offerings

With the current, rapid pace of new genetic discoveries, inherited disease testing is quickly becoming a common part of clinical veterinary diagnostics. Paw Print Genetics is excited to announce the release of six new canine genetic disease tests, including highly anticipated tests for three diseases in retriever breeds; macular corneal dystrophy and congenital myasthenic syndrome in the Labrador retriever and neuronal ceroid lipofuscinosis 5 in the golden retriever.

Macular Corneal Dystrophy

With an estimated mutation carrier rate of 3.3% in a 2015 study of the UK Labrador retrievers, macular corneal dystrophy (MCD) is an inherited eye disease that that is likely to be encountered at some point in a small animal veterinarian’s career1.

Inherited in a recessive manner, Labradors with two copies of the associated CHST6 gene mutation typically present in middle age with MCD-associated vision loss. Affected dogs display decreased activity of an enzyme known as corneal glucosamine N-acetyl-6-sulfotransferase (C-GlcNAc6ST), which results in decreased sulfation of the corneal glycosaminoglycan, keratin sulfate (KS). Decreased sulfation of KS reduces its solubility, thus preventing its full metabolism and allowing for deposition into the extracellular space of the corneal stroma and Desmet’s membrane, and intracellularly in keratinocytes and corneal epithelial cells ...

Does Your Dog Suffer from Noise Anxiety?

Does Your Dog Suffer from Noise Anxiety?

Summertime is usually a very positive time for our pets.  The weather is pleasant, walks are more frequent, and general outside playtime is more regular.  Unfortunately, this is also the time of thunderstorms and increase fireworks use, especially around July 4th.  The loud noises associated with these events can cause fear and anxiety in some pets.  A new behavioral study out of the University of Helsinki suggests that sensitivity to noise, especially fireworks, is the most common form of anxiety in pet dogs.  In this study, 72.5% of all dogs showed some type of anxiety, whereas, 32% displayed a form of noise sensitivity1.

People who own pets with noise sensitivity usually recognize the classic display of anxiety behaviors such as trembling, panting, drooling, pacing, vocalizing, hiding, and trying to escape.  Often, dogs are confused about the source of the noise and therefore try to escape to the outside, or just the opposite, scratch at the door to come inside.  Because some rooms are better at dampening sound, these dogs may run to the basement or hide under or behind furniture. There are some displays of anxiety that owners may not pick ...