Tag archives: genetic testing

It does not come as a surprise to veterinarians that many of the diseases they see in clinical practice have a hereditary component. If a genetic disease is amenable to treatment, veterinarians are typically well equipped to improve quality of life based upon their patient’s clinical signs. However, since clinical signs alone don’t always point to a specific definitive diagnosis, veterinarians treating inherited disease are often left with unanswered questions about the root cause of the medical problem. Paw Print Genetics offers genetic testing for over 140 different genetic diseases to help veterinarians shorten their list of differential diagnoses and identify the specific genetic mutation responsible for causing the clinical signs they are seeing, thereby, allowing for more specific therapies and recommendations to be made for the benefit of their patients.

Breed Specific Genetic Testing

Many inherited conditions seen in dogs are breed specific or have only been described in particular breeds or breed groups. For instance, one specific mutation in the canine HSF4 gene responsible for early-onset hereditary cataracts has only been described in the Australian shepherd and closely related breeds. Searching a specific breed or symptom on the Paw Print Genetics website will simplify the process of choosing ...

For many years, an extensive physical exam, fecal sample testing, vaccinations, and deworming have been the mainstays of new puppy veterinary visits. While all of these tried and true steps are crucial in making sure that a puppy is healthy and stays that way, advances in genetic testing technologies are now revolutionizing the veterinarian’s approach to addressing and anticipating potential health issues in young dogs. Though inherited diseases are seen by veterinarians on a frequent basis, many veterinarians do not realize that genetic testing for diseases is available or understand how clinically helpful testing puppies at their first visit can be. How often do you discuss puppy genetic testing with your clients?

How Can Genetic Testing Improve Veterinary Practice?

The implications that genetic testing results can have for a dog’s veterinary care vary by a specific disease’s age of onset, progression, and clinical signs. Early diagnosis of late-onset inherited diseases allows for your clients to become educated about what to expect and in some cases, take preventative measures and plan for life changes. Knowledge that a dog is at-risk for a particular late-onset disease also allows for early diagnosis and implementation of early treatment when possible. In some cases, clients ...

The most common question that I receive goes something like this…”I have an upcoming litter.  How do I take advantage of this great sale before the pups have names and registration numbers?”

Paw Print Genetics provides a lot of services ‘behind the scenes’ that you may not know about.  Here we review our most popular services – all at no extra charge to you!

You can order tests for your pups before they are born!  Place an order with Paw Print Genetics anticipating the number of pups you are expecting. Name each pup a separate name, such as pup1, pup2, etc. Once they are born, you can update each pup with their birth date and sex. You can edit their name and add a collar color or some other identifier like coat color. Now you are ready to send in your samples!

Review all of our samples types because some samples, like dewclaws and umbilical cords will get you results much sooner than waiting on the best time to do cheek swabs in a puppy.

If you over estimated your litter size or just wanted to order extra tests to take advantage of the savings, you ...

Most veterinarians are well aware that canine hip and elbow radiographs, echocardiograms, and eye examinations have become routine veterinary health clearances requested by dog breeders. The goal of these diagnostics is to help breeders to improve their blood lines and produce healthy puppies. However, unless you work in a practice with a heavy canine reproduction case load, it is likely that you are less familiar with the genetic testing employed by breeders, what genetic tests are available, and how the results of genetic testing can help your dog-breeding clients attain their goals. Now that genetic testing has become a common addition to other pre-breeding canine health testing, gaining an understanding of available genetic testing and offering a service to help your clients complete their genetic testing through Paw Print Genetics (PPG), may increase the value of your customer relationships and build client loyalty, while at the same time, fulfilling your veterinary goal to improve the quality and length of puppies’ lives. How often do you discuss genetic testing with your dog breeder clients?

Dog Breeding and Genetic Testing

Though vet school curriculums have historically addressed canine inherited diseases and treatments for these conditions, much less emphasis has been placed on ...

2015 was a big year for Paw Print Genetics. We made improvements to our website for easier account management, launched new disease tests, coat colors and traits, and won our lawsuit over Labrador exercise-induced collapse (EIC), so that you have choice in testing laboratories.

Our account management system is the best in the industry, but we are always looking for new ideas. Some of the website improvements made in 2015 include the ability to hide dogs within your account, share dogs between accounts and move dogs to new accounts.  What would you like to be able to do in your account? We continue to make improvements to our testing, reporting and website, all based on your input.

In early January, we launched several new, important disease tests including hereditary cataracts for Australian shepherds and related breeds and hereditary cataracts for French bulldogs and related breeds.  We also launched two progressive retinal atrophies in the golden retriever and retinal dysplasia/oculoskeletal dysplasia in Labrador retrievers.  We have many additional tests on our list to develop in 2016. We look forward to bringing you those tests throughout the new year.

Paw Print Genetics now offers 10 coat color tests and ...

This is a special time of year; the time of year when we reflect on all of the things for which we are thankful. Good health, warm houses and loved ones are just a few of the things that we can be thankful for throughout the year. Paw Print Genetics is very thankful and grateful for our customers, large and small.  Without the responsible breeders and individuals who care deeply about canine health, we would not be here. We take pride in serving you the best way we know how.

Paw Print Genetics works very hard to provide you the best genetic testing and customer service in the industry. We are proud to provide you with so many little extras to help you better care for your dogs. Some of the little things that matter include online account management, providing you changes to your dog’s reports at no charge, as you select the best and register those for the future, and providing Paw Print Pedigrees so that you can show the world that you are a responsible breeder.

In addition to our customers, I am thankful for our amazing staff of molecular technologists, PhD geneticists and veterinarians that are dedicated to ...

Paw Print Genetics has begun a new series of blogs aimed at helping veterinarians integrate genetics into their practice. These blogs help illustrate how the veterinarian might include discussions about genetics during new puppy visits, while helping a breeder with their breeding program, or considering genetic causes in developing a differential diagnosis for symptomatic dogs.

Veterinarians can assist clients in receiving genetic services in several ways. First, the vet may simply provide the dog owner information about testing options and clarify any questions that they might have.  Second, the veterinary staff assists the owner in setting up an individual account and performs the blood draw or cheek swabbing for the customer.  In this case, the genetic results would be uploaded to the customer’s account and the customer would have direct access to the information. Third, the veterinary clinic can set up a master account on the Paw Print Genetics website. Each customer’s dog is entered into the master account as orders are placed. For each dog, there is a field that allows the clinic staff to enter the dog owner’s name and contact information. After testing, the genetic results are uploaded to the clinic’s master account and the ...

"What's in a name? That which we call a rose by any other name would smell as sweet." That famous quote by William Shakespeare conjures up images that any name will do. But will it?  How do you choose names for your dogs?

In our household, we all participate in thinking up names for our new dogs. However, when it comes to decision time, my husband or myself usually make the final determination.  Otherwise, we would have more than just a pygmy goat named Princess Ariel Diamond!

At Paw Print Genetics, our online account management system allows you to put all of your dogs into your account, keeping your information and genetic testing results all in one place.  We see some fantastic and imaginative names come through our laboratory.  We thought it would be fun to see what names are most commonly used.

The top ten call names that we have seen in the laboratory across all breeds are:

10^th     Duke

9^th       Maggie

8^th       Lily

7^th       Lucy

6^th       Max

5^th       Gracie

4^th           Penny

3^rd           Sadie

2^nd           Bella

1^st       Annie

Some ...

At Paw Print Genetics, we offer nearly 200 different breed-specific panels. We are often asked "why choose a breed-specific panel?".  Choosing a breed-specific panel will help you avoid introducing a new genetic disease into your breeding program while saving you time, money and anguish in the future.  Here's why:

1. Test your dam and sire with the breed-specific panel before you breed. 

Performing a complete, breed-specific panel on your dam and sire will help you make an informed decision to breed or not to breed.

Testing first the dam and sire with an entire panel also saves money in the long run by reducing the need to test their future puppies. This is because puppies will be clear for a disease if both tested parents are also clear for that disease. Therefore, the puppies sold as future breeding stock will only need to be tested for any disease-causing mutations found in the parents. If both parents are clear of all disease-causing mutations, no testing of the puppies is necessary.

2. Test your new puppy with the entire breed-specific panel before you buy.

Introducing a new dog into your breeding program is always a little risky. Although you can’t exclude ...

Degenerative myelopathy (DM) can be a devastating disease. Some breeds with this disease will lose the ability to walk in their later years – certainly after the age most dogs are bred. The mutation has been found in more than 120 breeds (1), which indicates that the original mutation might have occurred hundreds or thousands of years before many of the modern dog breeds emerged.

However, the frequency of the mutation varies between breeds and certainly the risk of developing the clinical disease seems quite distinct and breed-specific. For example, the frequency of carriers and homozygous mutation (affected) dogs in the Kerry blue terrier is about 52%(1), while carriers and affected dogs make up 91% of Pembroke Welsh corgis in Japan(2). Although wire fox terriers have a similar combined carrier and at-risk frequency of 90%, none have ever developed the clinical signs of DM(3).

In a 2001 study by Moore et al., German shepherd dogs had nearly twice the risk for death associated with spinal cord diseases, compared with Belgian shepherd dogs among military dogs(4).  Although we don’t know for sure if the spinal cord disease was DM, certainly DM is one of the more common causes of this ...