Tag archives: Rhodesian ridgeback

Paw Print Genetics Launches Twelve New, Highly Desired Disease Tests

Paw Print Genetics Launches Twelve New, Highly Desired Disease Tests
Thank you to the many PPG customers who offered photos for this important announcement. The photos in the first two rows were selected from a large number of customers who provided photos for this article.

Paw Print Genetics is excited to announce that it has launched 12 new, very sought-after disease tests.  These tests compliment the breed-specific assays that PPG already offers, and cements our dedication to providing the largest menu of genetic tests for dogs. The following tests can be ordered as individual tests or may be part of one of our breed-specific panels that should be considered for any breeding dog.

Degenerative Myelopathy in the Bernese Mountain Dog

The Bernese Mountain Dog (BMD) has been identified as breed that can inherited degenerative myelopathy (DM). In this particular breed, two different mutations in the SOD1 gene have been identified. Degenerative myelopathy SOD1B is caused by a mutation of the SOD1 gene currently identified only in the Bernese mountain dog that is a different mutation from the common SOD1 mutation causing DM in a large number of breeds.  Bernese mountain dogs are known to develop a more slowly progressive form of degenerative myelopathy associated with the SOD1B mutation.  Both types of DM affect the white matter tissue of the spinal cord and is considered the canine equivalent to amyotrophic lateral sclerosis (Lou Gehrig’s disease) found in humans. Affected dogs usually present around 8-9 ...

Dermoid Sinus: Are we on the “ridge” of a paradigm shift?

Dermoid Sinus: Are we on the “ridge” of a paradigm shift?

Since early in canine domestication, humans have been selecting individual dogs with desirable behavioral and physical traits to be founder breeding animals for the hundreds of dog breeds we have today. Early on, the traits selected for were often of great importance for their role as working animals. With time, as the world of dog fanciers took shape, dogs with particular physical traits of aesthetic value began to be the chosen bearers of future generations regardless of their ability to work. Unfortunately however, there are multiple examples of selected physical traits that are significant risk factors for disease.

One important example is a disorder seen in Rhodesian ridgeback (RR) dogs known as a dermoid sinus that has been associated with the characteristic “ridge” trait in the skin overlying the spine. In 2007, a large genetic duplication on canine chromosome 18 was identified as the underlying genetic cause of the ridge in this breed.2 Unfortunately, the same genetic duplication responsible for ridge formation has also been found to predispose RRs to formation of dermoid sinuses.1,2

Dermoid sinuses are tubular to round shaped cavitations in the skin often filled with hair and keratin that are present at birth. It ...