Tag archives: Cancer in my German shepherd

Germline and Somatic Genetic Mutations in Dogs

Germline and Somatic Genetic Mutations in Dogs

My last blog discussed the complexity of inherited cancer predisposition syndromes.  A concept was introduced about the types of genetic mutations that can predispose a dog (or human) for cancer.  Some genetic mutations are passed through the blood line, while other genetic mutations are NOT passed on to the next generation.  Today, I would like to address this idea in greater detail.  These genetic mutations are called germline and somatic

Germline mutations are passed through the generations.  These are the mutations that show different modes of inheritance: dominant, recessive, X-linked, and mitochondrial.  Germline mutations are present in the sex cells (sperm and/or egg) and can affect multiple pups in a litter.  These are the mutations Paw Print Genetics offers testing for, which may impact breeding practices.  Breeders equipped with this information have the power to reduce, and maybe even eliminate, these mutations from breeding lines.  

Somatic mutations are genetic changes in the cells of the individual.  These mutations are usually not present at birth and can occur in any cell or organ over time.  These are usually due to environmental influences, although the exact triggers are often ...