Tag archives: late onset

If you are anything like me, planning for Mother’s Day can be like planning for a future litter of puppies. Caught up in the whirlwind of life, work, fun, kids and family, sometimes the important planning that goes into celebrating our mom or getting our prospective canine mothers prepped for their 9-week puppy rearing adventure, slips to the bottom of the “to do” list.

Luckily, most human moms are easy to please if we simply make a small effort to show that we care. An eleventh hour bouquet of flowers or a last minute lunch date is often enough to let mom know that she really matters, despite our procrastination. Unfortunately for the canine mothers in our life, procrastination in regards to planning a new dam’s first litter, can mean the difference between a healthy group of puppies and a sickly one. In addition to setting aside the time for veterinary health clearances of the heart, eyes, hips, and elbows, genetic testing of a new potential dam (or sire, for that matter) is of utmost importance to puppy health and the reputation of your breeding program. Unfortunately, accidentally putting off genetic testing until your dam is fully ready to breed ...

After many inquiries by our wonderful clients, Paw Print Genetics is excited to announce that we have begun testing for two genetic mutations reported to cause progressive retinal atrophy in the golden retriever. Known specifically as progressive retinal atrophy, GR1 and GR2 (PRA-GR1 and PRA-GR2), these two diseases were found to be caused by genetic mutations in the SLC4A3 and TTC8 genes, respectively. In addition to the golden retriever, the TTC8 mutation that causes PRA-GR2 has also been identified in a clinically affected Labrador retriever.

Progressive retinal atrophy (PRA) is not a single disease, but rather a group of inherited diseases each caused by different genetic mutations in different genes. The various forms of PRA affect over 100 different dog breeds. Though there are variations in the progression of disease, most varieties of PRA (regardless of genetic cause) result in blindness due to an inherited degeneration of the retina; more specifically, the degeneration of retinal cells known as rods and cones, which play an important role in vision.

In PRA-GR1 and PRA-GR2, signs of night blindness and loss of peripheral vision are seen first with progression to complete blindness occurring over time. In addition, they are both considered late onset ...