Tag archives: basset hound

Paw Print Genetics Launches Twelve New, Highly Desired Disease Tests

Paw Print Genetics Launches Twelve New, Highly Desired Disease Tests
Thank you to the many PPG customers who offered photos for this important announcement. The photos in the first two rows were selected from a large number of customers who provided photos for this article.

Paw Print Genetics is excited to announce that it has launched 12 new, very sought-after disease tests.  These tests compliment the breed-specific assays that PPG already offers, and cements our dedication to providing the largest menu of genetic tests for dogs. The following tests can be ordered as individual tests or may be part of one of our breed-specific panels that should be considered for any breeding dog.

Degenerative Myelopathy in the Bernese Mountain Dog

The Bernese Mountain Dog (BMD) has been identified as breed that can inherited degenerative myelopathy (DM). In this particular breed, two different mutations in the SOD1 gene have been identified. Degenerative myelopathy SOD1B is caused by a mutation of the SOD1 gene currently identified only in the Bernese mountain dog that is a different mutation from the common SOD1 mutation causing DM in a large number of breeds.  Bernese mountain dogs are known to develop a more slowly progressive form of degenerative myelopathy associated with the SOD1B mutation.  Both types of DM affect the white matter tissue of the spinal cord and is considered the canine equivalent to amyotrophic lateral sclerosis (Lou Gehrig’s disease) found in humans. Affected dogs usually present around 8-9 ...

Thrombopathia: A Preventable Inherited Disease of the Basset Hound

Thrombopathia: A Preventable Inherited Disease of the Basset Hound

Since the first exhibitions of the modern basset hound in the late 19th century, their mellow and charming personality has made them a popular family dog. Though according to the Basset Hound Club of America, it is not unusual for a basset hound to be a little stubborn or to have “selective hearing” (especially if following a scent trail), this minor annoyance is easily tempered by their affectionate and sensitive disposition. Originally bred for hunting with a person on foot, the basset hound’s short legs kept them from outrunning their handler while following their exceptional nose. Unfortunately, like other purebred dogs, the basset hound has also been unable to outrun susceptibility to certain inherited diseases. One such condition is a disease of blood platelets known as thrombopathia that occurs due to a mutation in the RASGRP1 gene.

Dogs affected with thrombopathia produce a dysfunctional form of a protein important in the aggregation of platelets during blood clotting. The resulting inability to produce functional blood clots leads to easy bruising and frequent episodes of spontaneous bleeding from the gums, nose, and the gastrointestinal tract. Affected dogs may also show signs of lameness due to spontaneous bleeding in joints. Loss of ...