Archives for Dec. 31, 2014

Primary Hyperoxaluria: A Preventable Inherited Disease of the Coton de Tulear

Primary Hyperoxaluria: A Preventable Inherited Disease of the Coton de Tulear

There are not many dog breed names that give a more apt description of the breed’s physical appearance than that of the coton de Tulear. Taken from the French word “coton”, meaning cotton, the coton de Tulear’s signature soft white hair (not fur) has long been compared to the fluffy fiber of the cotton plant. According to the Malagasy Coton de Tulear Club of America, the coton de Tulear was developed in Madagascar around the 17th century and is still the official dog of this island nation. Predecessors to the modern coton de Tulear were likely brought to the island by sailors or pirates around this time period. Though they are generally a healthy breed, unfortunately, like other purebred dogs, the coton de Tulear is known to inherit some genetic diseases that can make life challenging for this small, friendly companion and those that love them. One such inherited disease of the coton de Tulear is a severe condition known as primary hyperoxaluria (PH) that occurs due to a mutation in the AGXT gene.

Dogs affected with PH lack the ability to produce an enzyme that plays an essential role in the breakdown of a compound known as glyoxylate ...