Tag archives: genetics

2015 was a big year for Paw Print Genetics. We made improvements to our website for easier account management, launched new disease tests, coat colors and traits, and won our lawsuit over Labrador exercise-induced collapse (EIC), so that you have choice in testing laboratories.

Our account management system is the best in the industry, but we are always looking for new ideas. Some of the website improvements made in 2015 include the ability to hide dogs within your account, share dogs between accounts and move dogs to new accounts.  What would you like to be able to do in your account? We continue to make improvements to our testing, reporting and website, all based on your input.

In early January, we launched several new, important disease tests including hereditary cataracts for Australian shepherds and related breeds and hereditary cataracts for French bulldogs and related breeds.  We also launched two progressive retinal atrophies in the golden retriever and retinal dysplasia/oculoskeletal dysplasia in Labrador retrievers.  We have many additional tests on our list to develop in 2016. We look forward to bringing you those tests throughout the new year.

Paw Print Genetics now offers 10 coat color tests and ...

This is a special time of year; the time of year when we reflect on all of the things for which we are thankful. Good health, warm houses and loved ones are just a few of the things that we can be thankful for throughout the year. Paw Print Genetics is very thankful and grateful for our customers, large and small.  Without the responsible breeders and individuals who care deeply about canine health, we would not be here. We take pride in serving you the best way we know how.

Paw Print Genetics works very hard to provide you the best genetic testing and customer service in the industry. We are proud to provide you with so many little extras to help you better care for your dogs. Some of the little things that matter include online account management, providing you changes to your dog’s reports at no charge, as you select the best and register those for the future, and providing Paw Print Pedigrees so that you can show the world that you are a responsible breeder.

In addition to our customers, I am thankful for our amazing staff of molecular technologists, PhD geneticists and veterinarians that are dedicated to ...

Recently the Paw Print Genetics team attended the AKC Canine Health Foundation’s 2013 National Parent Club Canine Health Conference in St. Louis. The conference was held at the Hyatt Regency and consisted of three days of presentations, studies and the future of canine health across many topics.

Presentations and speakers included: “Inherited Cardiomyopathies” by Kathryn Meurs, DVM, PhD of North Carolina State University; “Regenerative Medicine for Soft Tissue Injuries in the Canine” by Sherman O. Canapp Jr., DVM, MS, CCRT of Veterinary Orthopedic and Sports Medicine Group; “Application of Physical Therapy Techniques to Our Canine Patients: The Current Science and Research Opportunities” by Janet B. Van Dyke, DVM, DACVSMR of the Canine Rehabilitation Institute; as well as breakout sessions covering cancer, nutrition/GI/bloat and, of course, genetic testing.

This is a chance for AKC Canine Health Foundation grantees to show how the monies from the organization are being used, to update parent breed clubs on their findings and what they still need to investigate, as well as to receive feedback from the clubs themselves.

While taking a quick break, I ran into Susan LaCroix Hamil, who is on the Board of Directors for both the AKC Canine Health Foundation ...

Another non-intuitive but common behavior of genes is that one gene can have different but apparently unrelated effects. This is somewhat the opposite of different genes having the same effect (discussed in my previous blog). Making it even more confusing, the same condition could have both at work!

One gene may create a specific appearance but can also cause issues that would not necessarily appear to be related. In scientific terms the word pleiotropy is used to refer to the phenomenon "when one allele or pair of alleles has different effects - particularly when these effects appear unrelated."

Many examples of this phenomenon exist in the dog world. With on-going research, more will no-doubt be identified.

The gene causing Merle color pattern increases the chance for deafness and eye defects. Certain "white" dogs also have increased risk of deafness related to being white. In other breeds, very white appearing dogs (due to other genes) and dogs with albinism have no associated risk for hearing loss. In the case of the Merle and "white piebald" associations the effect begins on cells derived from the neural crest affecting both pigment, auditory and potentially other neural-derived cells, but not all Merles, double merles and ...

One of the key issues that people often have in grappling with genetics disease is the fact that genes and disorders that are supposedly genetic don't always make sense (or at least not the sense that people expect them to make.) What they see occur does not pass their intuition or logic of what they think they should see if the condition is really "genetic."

A problem will be identified that has never occurred before and people will say in all honesty---"that has never happened in my line" and yet they are told it is "genetic." This happens in human families as well. A genetic condition is diagnosed in a child and the first thing that both grandmothers say is "that did not come from our side of the family!" In some cases they may be wrong and in others they may be right. Different genes follow different "rules."

Recessive disorders in fact come from both families and are due simply to the fact that both the sire and dam happened to carry the same detrimental recessive gene. These can be passed on for many generations unrecognized and only revealed when two carriers happen to mate AND both ...