Tag archives: anemia

Prevention Is Smart Breeding- PFK Deficiency in the English Springer Spaniel

Prevention Is Smart Breeding- PFK Deficiency in the English Springer Spaniel

Likely originating in Spain, the spaniel family of dogs have long been important companions to bird hunters around the world. As late as the 1880’s, springer and cocker spaniels were born in the same litters and were only differentiated by size after birth. Dogs under 28 pounds were considered “cockers” and were used for their ability to hunt the small wading bird known as the woodcock while the larger “springers” were used to flush game birds to be captured by trained birds of prey (which were later replaced by firearms). Separate breed status for cocker and springer spaniels was established in 1902 by the Kennel Club of England and the English springer spaniel (ESS) was formally recognized by the American Kennel Club in 1910. Since that time, the ESS has been further differentiated into the leaner and less densely haired “field” variety and the heavier boned and thicker coated show or “bench” lines.

Like other breeds, along the historical path to the modern ESS, the breed has developed some inherited disease concerns that keep breeders on their toes. Luckily, some of these inherited diseases can be eliminated from blood lines though the use of genetic testing technologies and selective breeding ...

Thrombopathia: A Preventable Inherited Disease of the Basset Hound

Thrombopathia: A Preventable Inherited Disease of the Basset Hound

Since the first exhibitions of the modern basset hound in the late 19th century, their mellow and charming personality has made them a popular family dog. Though according to the Basset Hound Club of America, it is not unusual for a basset hound to be a little stubborn or to have “selective hearing” (especially if following a scent trail), this minor annoyance is easily tempered by their affectionate and sensitive disposition. Originally bred for hunting with a person on foot, the basset hound’s short legs kept them from outrunning their handler while following their exceptional nose. Unfortunately, like other purebred dogs, the basset hound has also been unable to outrun susceptibility to certain inherited diseases. One such condition is a disease of blood platelets known as thrombopathia that occurs due to a mutation in the RASGRP1 gene.

Dogs affected with thrombopathia produce a dysfunctional form of a protein important in the aggregation of platelets during blood clotting. The resulting inability to produce functional blood clots leads to easy bruising and frequent episodes of spontaneous bleeding from the gums, nose, and the gastrointestinal tract. Affected dogs may also show signs of lameness due to spontaneous bleeding in joints. Loss of ...