Laryngeal Paralysis and Polyneuropathy (Leonberger Type 3) is an inherited neurological disease affecting dogs. Affected dogs typically present with clinical signs at less than 5 years of age including difficulty breathing, often described as loud and harsh, difficulty swallowing, and changes in the dog’s vocalizations. In severe cases, a dog’s mobility may be affected by an uncoordinated gate, stumbling and tripping, exercise intolerance and muscle deterioration. In some dogs, this condition may be managed with conservative measures such as changes in lifestyle while others require surgical treatment to reduce severe respiratory signs. This condition may result in emergent respiratory distress or aspiration pneumonia which can be fatal.