Junctional Epidermolysis Bullosa (Australian Shepherd type) is a hereditary skin disease affecting dogs. Affected dogs typically present within a few weeks of age with fragile skin that is easily damaged from rubbing or trauma resulting in blisters and ulcers. Areas that are most prone to blisters are the face, foot pads, and ears. The skin around the toenails may be affected causing them to slough. In addition, affected dogs can develop blisters and ulcers inside the mouth, throat, and esophagus. Ulcerations of the skin and mucous membranes are painful and can become infected. Affected dogs are smaller than littermates, likely due to difficulties eating. Affected dogs are often euthanized within a few months of age due to poor quality of life.