GM1 gangliosidosis (shiba inu type) is an inherited Lysosomal Storage Disorder affecting dogs. Affected dogs typically present with symptoms of neurologic disease around 5 to 6 months of age. Dogs with GM1 gangliosidosis have insufficient activity of the Enzyme beta-galactosidase, which is responsible for breaking down specific carbohydrates in the cells. As a result, there is an accumulation of break down products such as GM1 in cells, especially cells of the brain and nervous system. Symptoms include vision loss, difficulties walking, loss of balance, head tremors, lethargy and weight loss. By 9 to 12 months of age affected dogs are lethargic, have cloudy corneas, and may have involuntary muscle contractions. Dogs usually die by 15 months of age.