Lafora disease is an inherited neurological disease affecting beagles. Affected dogs typically present after 5 years of age with progressive, partial to generalized seizures due to an abnormal accumulation of large carbohydrate molecules in the brain. As the disease progresses, affected dogs may display other clinical signs including vision loss, deafness, Dementia, myoclonus (involuntary muscle jerks), aggression, tremors, “flybiting” behavior (attempting to catch nonexistent flies), jaw smacking, urinary and fecal incontinence, loss of house training, and/or abnormal gait. Excitement or nervousness, exposure to flickering lights, sudden sounds or movements may trigger seizure activity in some affected dogs. Seizures associated with Lafora epilepsy have mixed response to treatment, becoming less effective as the disease progresses. Affected dogs are typically euthanized by 10-12 years of age due to decline in quality of life.