Dry eye curly coat syndrome is an inherited disease that affects the eyes, skin, and feet of dogs. Affected dogs are usually diagnosed between 2-10 weeks of age with keratoconjuncitivits sicca and ichthyosiform dermatosis. Keratoconjunctivitis sicca, commonly called “dry eye”, is the result of abnormal tear production. Affected dogs often have mucoid, green discharge around their eyes and can develop severe corneal ulcers. Ichthyosiform dermatosis in affected Cavalier King Charles Spaniels is characterized by frizzy sparse hair, dry flakey skin, thickened foot pads, and malformed nails. The skin on the footpads and nails can slough and make standing and walking painful for affected dogs. Affected dogs are also predisposed to dental disease.