Familial Nephropathy (English Springer Spaniel Type)

Other Names: Hereditary nephropathy, Nephropathy, FN, HN
Affected Genes: COL4A4
Inheritance: Autosomal Recessive
Mutation: chr25:39893376 (canFam3): C>T
Breed(s): English Springer Spaniel

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Common Symptoms

Familial nephropathy (English springer spaniel type) is an inherited disorder of the kidneys affecting dogs. Normally protein is not present in the urine, but in affected dogs there is a defect that allows protein from the blood to be filtered by the kidneys and lost in the urine. Abnormal amounts of protein can be detected in the urine usually between 4-6 months of age. Symptoms of chronic kidney disease begin a few months after excessive protein is noted in the urine. Symptoms of chronic kidney disease include excessive thirst and urination, vomiting, inappetence, weight loss, weakness and fatigue. If drinking excessively, some dogs may also inappropriately urinate in the house or in a crate. Affected dogs typically die of chronic kidney failure by one to two years of age.

Testing Tips

Genetic testing of the COL4A4 gene will reliably determine whether a dog is a genetic Carrier of familial nephropathy (English springer spaniel type). Familial nephropathy (English springer spaniel type) is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease. In general, carrier dogs do not have features of the disease but when bred with another carrier of the same Mutation, there is a risk of having affected pups. Each pup that is born to this pairing has a 25% chance of inheriting the disease and a 50% chance of inheriting one copy and being a carrier of the COL4A4 gene mutation. Reliable genetic testing is important for determining breeding practices. In order to eliminate this mutation from breeding lines and to avoid the potential of producing affected pups, breeding of known carriers to each other is not recommended. Dogs that are not carriers of the mutation have no increased risk of having affected pups.

There may be other causes of this condition in dogs and a normal result does not exclude a different mutation in this gene or any other gene that may result in a similar genetic disease or trait.


  • Nowend KL, Starr-Moss AN, Lees GE, Berridge BR, Clubb FJ, Kashtan CE, Nabity MB, Murphy KE. Characterization of the genetic basis for autosomal recessive hereditary nephropathy in the English Springer Spaniel. J Vet Intern Med. 2012 Mar-Apr; 26(2):294-301. [PubMed: 22369189]