Congenital Hypothyroidism with Goiter (Terrier Type)

Other Names: CHG
Affected Genes: TPO
Inheritance: Autosomal Recessive
Mutation: Point Mutation

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Common Symptoms

Congenital hypothyroidism with goiter (CHG) is an inherited disease affecting dogs. Affected dogs lack an Enzyme that is important in the production of thyroid hormone which is necessary for the normal development and metabolism of dogs. At 3-8 weeks of age, dogs with CHG are generally noted to have reduced movement and to be small when compared to their littermates. Enlarged thyroid glands (goiter) are often noticeable as a swelling on the neck. Affected puppies exhibit dwarfism with short legs, large heads, and fluffy hair coats absent of guard hairs. In addition, affected dogs develop a wide variety of neurological and neuromuscular deficits. The condition progresses to failure to thrive and death. Most symptoms can be prevented or will regress if the condition is diagnosed early and affected dogs are treated with thyroid hormone medication. However, the thyroid glands may continue to enlarge over time despite treatment and can eventually obstruct the dog’s airway.


Breed-Specific Information for the Toy Fox Terrier

The Mutation of the TPO gene associated with congenital hypothyroidism with goiter (terrier type) has been identified in toy fox terriers, although its overall frequency in this breed is unknown.


Testing Tips

Genetic testing of the TPO gene in toy fox terriers will reliably determine whether a dog is a genetic Carrier of congenital hypothyroidism with goiter (terrier type). Congenital hypothyroidism with goiter (terrier type) is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease. In general, carrier dogs do not have features of the disease but when bred with another carrier of the same Mutation, there is a risk of having affected pups. Each pup that is born to this pairing has a 25% chance of inheriting the disease and a 50% chance of inheriting one copy and being a carrier of the TPO gene mutation. Reliable genetic testing is important for determining breeding practices. In order to eliminate this mutation from breeding lines and to avoid the potential of producing affected pups, breeding of known carriers to each other is not recommended. Toy fox terriers that are not carriers of the mutation have no increased risk of having affected pups.


There may be other causes of this condition in dogs and a normal result does not exclude a different mutation in this gene or any other gene that may result in a similar genetic disease or trait.


References

  • Bojanic K, Acke E, Jones BR. Congenital hypothyroidism of dogs and cats: a review. N Z Vet J. 2011 May; 59(3):115-22. [PubMed: 21541884]
  • Ferguson DC. Testing for hypothyroidism in dogs. Vet Clin North Am Small Anim Pract. 2007 Jul; 37(4):647-69, v. [PubMed: 17619004]
  • Fyfe JC, Kampschmidt K, Dang V, Poteet BA, He Q, Lowrie C, Graham PA, Fetro VM. Congenital hypothyroidism with goiter in toy fox terriers. J Vet Intern Med. 2003 Jan-Feb;17(1):50-7. [PubMed: 12564727]
  • Pettigrew R, Fyfe JC, Gregory BL, Lipsitz D, Delahunta A, Summers BA, Shelton GD. CNS hypomyelination in Rat Terrier dogs with congenital goiter and a mutation in the thyroid peroxidase gene. Vet Pathol. 2007 Jan; 44(1):50-6. [PubMed: 17197623]