Intestinal cobalamin malabsorption (giant schnauzer type) is an inherited disease affecting dogs. Affected dogs are unable to make adequate amounts of a protein that plays a role in absorption of certain nutrients from the intestinal tract and kidneys, including the B vitamin, cobalamin. Symptoms begin as early as 6 to 12 weeks of age and include anorexia, lethargy, poor weight gain, and poor muscle mass. In rare circumstances, a severe neurological dysfunction called hepatic encephalopathy may develop leading to an altered mental state, seizures, coma and death. From a young age affected dogs have increased levels of methylmalonic acid, and an increase in certain proteins in their urine (a sign of cobalamin deficiency). Decreased production of blood cells in affected dogs results in Anemia and decreased numbers of neutrophils, a type of white blood cell. Affected dogs require cobalamin supplementation for life. Most animals respond to treatment within a few weeks. Though not associated with clinical disease, affected dogs will continue to pass increased amounts of certain proteins in their urine even with cobalamin supplementation.