Shar-pei autoinflammatory disease is an inherited immunologic disorder affecting dogs. Affected dogs have recurrent episodes of fever and joint swelling, especially of the hocks. Symptoms typically present in the first few months of life, but some dogs may not show signs of disease until later in life. The first signs of disease have been reported in dogs up to 12 years of age, but most dogs will develop signs of the disease by 6 years of age. During episodes, dogs often display a fever and are typically lame in the swollen limb(s), lethargic, anorexic, and irritable. Though less common, joints of wrist, knee, hip, or jaw may also exhibit swelling. Episodes typically resolve on their own within 24-48 hours, but with treatment with anti-inflammatory drugs they may resolve faster. While affected dogs typically lead normal lives when not having episodes, they are predisposed to renal amyloidosis which leads to kidney failure. Shar-pei dogs with a padded (meatmouth) muzzle appear to be predisposed to developing this condition.