Protein-losing nephropathy is an inherited disorder of the kidneys affecting dogs. In healthy dogs, protein is not present in the urine, but in dogs affected with protein-losing nephropathy there is a defect that allows protein from the blood to be filtered by the kidneys and lost in the urine. Dogs typically present in middle-age with non-specific signs such as vomiting, diarrhea, and weight loss in addition to increased thirst and more frequent urination. If drinking excessively, some dogs may also inappropriately urinate in the house or in a crate. Occasionally affected dogs will also have edema and/or fluid accumulation in the abdomen or lungs. Dogs are typically euthanized within a few months after diagnosis due to the poor prognosis.