Pituitary dwarfism is a congenital growth hormone deficiency affecting dogs. Pituitary glands of affected dogs fail to develop normally, resulting in a deficiency of multiple hormones associated with growth and development. Affected dogs are smaller than littermates by 2 to 3 months of age and never attain normal adult size. Aside from growth deficiencies, affected dogs also display a characteristic retention of their soft, wooly puppy coat and fail to grow primary guard hairs. Various skin abnormalities are common and include scaling, bacterial infections, and hyperpigmentation. By 3 to 5 years of age, affected dogs often display severe Alopecia of the trunk, neck, and limbs and suffer from other disease associated complications such as mental dullness and kidney disease. If untreated, affected dogs often die or are humanely euthanized by 5 years of age due to concerns about quality of life.