Lagotto storage disorder is an inherited metabolic disorder affecting lagotto Romagnolos. Dogs with this disease produce inadequate amounts of an Enzyme which plays an important role in degradation, storage, and removal of cellular material from cells. As a result, this material accumulates in a variety of body’s cells, including those of the nervous system. The accumulation of this material results in an adult-onset progressive neurological disease most commonly presenting between 1 and 5 years of life. Clinical signs of neurological dysfunction in affected dogs include abnormal gait, weak or absent reflexes, limb weakness, behavioral changes, abnormal movement of the eyes (Nystagmus), aggression, restlessness, and depression. The speed of disease progression varies, but most affected dogs are euthanized months to years after initial clinical signs due to quality of life concerns.