Craniomandibular osteopathy is an inherited skeletal syndrome affecting dogs. Affected dogs often present at around four to eight months of age with signs of discomfort when eating or chewing caused by abnormal bone proliferation of the mandible, occipital and temporal skull bones, and/or the tympanic bulla (the bony structure housing the middle and inner ear). Other clinical signs of craniomandibular osteopathy include swelling around the jaw, difficulty opening mouth, drooling, fever, and difficulty holding food or toys with the mouth. Most dogs experience a cessation of bony growth around one year of age and the growth may recede or resolve in some cases with or without treatment. Although most cases of craniomandibular osteopathy are non-fatal, jaw pain in affected dogs may result in a reluctance to eat and secondary malnutrition. In some cases, pain and malnutrition may influence caregivers to pursue euthanasia due to quality of life concerns.