Acral mutilation syndrome is an inherited neurological disease affecting dogs. Affected dogs present around 4 months of age with an insensitivity to pain in the lower limbs and repetitive licking and biting of their paws, eventually resulting in self-mutilation. Affected dogs are often smaller than littermates and present with severe, self-induced wounds of the feet including toe amputations, loss of toenails, and bone fractures. Dogs with open wounds are subject to additional complications associated with secondary infections. Since affected dogs are unable to feel pain in their feet, they will continue to walk without obvious discomfort. Euthanasia is often requested by owners due to quality of life concerns and a lack of treatment options.