Neuroaxonal Dystrophy (Spanish Water Dog Type)

Other Names: NAD
Affected Genes: TECPR2
Inheritance: Autosomal Recessive

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Common Symptoms

Neuroaxonal Dystrophy (Spanish water dog type) is an inherited progressive neurological disease affecting Spanish water dogs. Affected dogs typically present between 6 months to 1 year of age with an abnormal gait, incontinence, and behavior changes including dullness, nervousness, and vocalization. Some dogs may also display vision loss and decreased muscle tone. Dogs are typically euthanized within a year of diagnosis due to disease progression.

Breed-Specific Information for the Spanish Water Dog

The Mutation of the TECPR2 gene associated with neuroaxonal dystrophy (Spanish water dog type) has been identified in Spanish water dogs, although its overall frequency in this breed is unknown.

Testing Tips

Genetic testing of the TECPR2 gene in Spanish water dogs will reliably determine whether a Spanish water dog is a genetic Carrier of neuroaxonal dystrophy (Spanish water dog type). Neuroaxonal dystrophy (Spanish water dog type) is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease. In general, carrier dogs do not have features of the disease but when bred with another carrier of the same Mutation, there is a risk of having affected pups. Each pup that is born to this pairing has a 25% chance of inheriting the disease and a 50% chance of inheriting one copy and being a carrier of the TECPR2 gene mutation. Reliable genetic testing is important for determining breeding practices. In order to eliminate this mutation from breeding lines and to avoid the potential of producing affected pups, breeding of known carriers to each other is not recommended. Spanish water dogs that are not carriers of the mutation have no increased risk of having affected pups.

There may be other causes of this condition in dogs and a normal result does not exclude a different mutation in this gene or any other gene that may result in a similar genetic disease or trait.


  • Hahn K, Rohdin C, Jagannathan V, Wohlsein P, Baumgärtner W, Seehusen F, Spitzbarth I, Grandon R, Drögemüller C, Jäderlund KH. TECPR2 Associated Neuroaxonal Dystrophy in Spanish Water Dogs. PLoS One. 2015 Nov 10;10(11). [PubMed: 26555167]