Leukocyte adhesion deficiency type III is an inherited blood disorder affecting German Shepherd Dogs. Affected dogs have abnormal platelet and white blood cell activity resulting in abnormal blood clotting and immune system function. Dogs may present with lameness, prolonged bleeding and recurrent, chronic infections especially of the skin and gums and often accompanied by fever. Other symptoms include persistently elevated white blood cell counts (leukocytosis). Dogs can live for years with this condition although they are susceptible to life-threatening bleeding with an accidental injury or any surgical procedure. Veterinarians performing surgery on known affected dogs should have ready access to blood banked for transfusions.