Amelogenesis imperfecta (AI) is an inherited disease of the teeth affecting Italian Greyhounds. Signs of disease are often noticed when baby teeth erupt. Affected dogs are unable to develop normal tooth enamel resulting in misshaped teeth with rough, irregular surfaces and gray or brown spotting. Affected permanent teeth are often smaller and more pointed than normal teeth. Premature, excessive enamel wear results in the appearance of larger than normal gaps between the teeth of affected dogs, even at an early age. Despite enamel defects, affected dogs are not at increased risk for periodontal disease and only rarely develop dental cavities or broken teeth.