Hereditary Cataracts

Other Names: Early onset cataracts, Juvenile cataracts, HC, JC
Affected Genes: HSF4
Inheritance: Autosomal Recessive
Mutation: chr5:82198104-82198105 (canFam3): 1 bp insertion (ins C)

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Common Symptoms

Hereditary Cataracts is an inherited eye disease in Staffordshire bull terriers. Cataracts are opacities in the lens of the eye caused by structural changes in lens proteins. A normal lens allows light to pass through it to the Retina in the back of the eye. Light cannot pass through the parts of the lens affected by cataracts and vision becomes blurry. Dogs with Hereditary Cataracts most commonly present within a few weeks to months after birth with small cataracts that are visible on a veterinary eye exam. Cataracts from this disease will eventually affect the whole lens in both eyes leading to complete blindness between 2-3 years of age. Of note, not all forms of cataracts are inherited and environmental factors such as UV damage can also play a role in the severity of disease.

Breed-Specific Information for the Staffordshire Bull Terrier

The Mutation of the HSF4 gene associated with Hereditary Cataracts has been identified in Staffordshire bull terriers, although its overall frequency in this breed is unknown.

Testing Tips

Genetic testing of the HSF4 gene in Staffordshire bull terriers will reliably determine whether a dog is a genetic Carrier of Hereditary Cataracts. Hereditary Cataracts in the Staffordshire bull terrier is inherited in an Autosomal Recessive manner meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease. In general, carrier dogs do not have features of the disease but when bred with another carrier of the same Mutation, there is a risk of having affected pups. Each pup that is born to this pairing has a 25% chance of inheriting the disease and a 50% chance of inheriting one copy and being a carrier of the HSF4 gene mutation. Reliable genetic testing is important for determining breeding practices. Because symptoms may not appear until adulthood, genetic testing should be performed before breeding. In order to eliminate this mutation from breeding lines and to avoid the potential of producing affected pups, breeding of known carriers to each other is not recommended. Staffordshire bull terriers that are not carriers of the mutation have no increased risk of having affected pups.

There may be other causes of this condition in dogs and a normal result does not exclude a different mutation in this gene or any other gene that may result in a similar genetic disease or trait.


  • Barnett KC. Hereditary cataract in the dog. J Small Anim Pract. 1978 Feb;19(2):109-20. [PubMed: 642468]
  • Mellersh CS, Graves KT, McLaughlin B, Ennis RB, Pettitt L, Vaudin M, Barnett KC. Mutation in HSF4 associated with early but not late-onset hereditary cataract in the Boston Terrier. J Hered. 2007;98(5):531-3. [PubMed: 17611257]
  • Mellersh CS, Pettitt L, Forman OP, Vaudin M, Barnett KC. Identification of mutations in HSF4 in dogs of three different breeds with hereditary cataracts. Vet Ophthalmol. 2006 Sep-Oct; 9(5):369-78. [PubMed: 16939467]