Leukocyte Adhesion Deficiency, Type I is an inherited immunodeficiency disorder affecting Irish Red and White Setters. Affected dogs have abnormal white blood cell (leukocyte) activity which results in a severely impaired immune system. Dogs usually develop symptoms shortly after birth and have recurrent infections throughout life. Symptoms include infections of the umbilicus, skin, bones, lungs and uterus as well as gingivitis, impaired wound healing, enlarged lymph nodes and low body weight. On blood work, affected dogs have persistently elevated white blood cell counts (leukocytosis). Without treatment puppies die within a few weeks of age. Even when treated with antibiotics, affected dogs will typically die by 6 months of age as a result of the recurrent and severe infections.