Canine multiple system degeneration (Chinese crested type) is a progressive inherited neurological disease affecting Chinese crested dogs. Affected dogs present at 3 to 6 months of age with tremors, abnormal gait and poor balance. Dogs gradually progress to severe gait abnormalities, balance issues, frequent falling, abnormal body posture, abnormal eye movement and eventually are unable to move. Dogs continue to show normal mental awareness and social behavior despite movement disturbances. Most dogs die due to disease complications or are humanely euthanized by 2 years of age.