Tag archives: golden retriever

One of the goals at Paw Print Genetics (PPG) is to add to our large menu of tests whenever we can. New genetic changes found in the dog genome for diseases and traits are published periodically in the medical literature. These publications guide us in developing new tests for our customers.

Among the new tests launched this month are three tests for traits. Two of the tests will identify whether a dog carries for polydactyly, which results in having hind dewclaws. One of the polydactyly variants in the LMBR1 gene will cause hind dewclaws in many different breeds, while the mutation in ALX4 only causes polydactyly in the Great Pyrenees. Both variants are dominant, meaning that one or two copies will result in polydactyly. Interestingly, the mutation for the Great Pyrenees causes double dewclaws, whereas the mutation in LMBR1 causes just single dewclaws.

The third trait launched is for another E locus variant. PPG offers several E locus variants, so it is important to read the description of each before choosing your test. Most breeds will produce a yellow or red coat color when there are two copies of the ‘e’ allele from the common E locus variant.  However ...

After many inquiries by our wonderful clients, Paw Print Genetics is excited to announce that we have begun testing for two genetic mutations reported to cause progressive retinal atrophy in the golden retriever. Known specifically as progressive retinal atrophy, GR1 and GR2 (PRA-GR1 and PRA-GR2), these two diseases were found to be caused by genetic mutations in the SLC4A3 and TTC8 genes, respectively. In addition to the golden retriever, the TTC8 mutation that causes PRA-GR2 has also been identified in a clinically affected Labrador retriever.

Progressive retinal atrophy (PRA) is not a single disease, but rather a group of inherited diseases each caused by different genetic mutations in different genes. The various forms of PRA affect over 100 different dog breeds. Though there are variations in the progression of disease, most varieties of PRA (regardless of genetic cause) result in blindness due to an inherited degeneration of the retina; more specifically, the degeneration of retinal cells known as rods and cones, which play an important role in vision.

In PRA-GR1 and PRA-GR2, signs of night blindness and loss of peripheral vision are seen first with progression to complete blindness occurring over time. In addition, they are both considered late onset ...

As entertaining, happy and hard-working dogs, golden retrievers have become one of the most popular breeds in the world. They consistently rank among the most-registered breeds in the U.S., U.K. and Australia, and serve many roles with an unrivaled eagerness to please.

Developed in Scotland in the 1800s as a water dog used to retrieve shot fowl, golden retrievers descend from a non-descript “yellow-colored” retriever, two extinct breeds (the St. Johns water dog and the Tweed water spaniel), Irish setters, the bloodhound and wavy-coated black retrievers. This combination of dogs set the stage for the modern golden’s characteristics: love of water, superb scenting ability, trainability, biddable disposition, desire to retrieve, soft mouth and intelligence. A well-balanced dog, golden retrievers possess soundness of body, character and intelligence (author Stanley Coren ranks them as the fourth most-intelligent dog).

While they were originally bred to retrieve waterfowl for hunters, and they still perform this duty today, golden retrievers have successfully crossed into all roles of canine athlete and assistance dog. Owners of golden retrievers compete in field trial and hunt tests, agility, flyball, obedience trials and the conformation ring. They are also used extensively in search and rescue, detection (from ...