Tag archives: cone-rod dystrophy

Canine progressive retinal atrophy (PRA) is a group of inherited eye diseases which are among the most common causes of inherited blindness in domestic dogs. Extensive study and characterization of the various PRAs have led to the discovery of well over a dozen different genetic mutations in many different genes which can now be identified to help prevent, predict, or diagnose PRA in many breeds. However, complicated PRA naming schemes and the breed-specific nature of the PRA tests can make it challenging for dog breeders or veterinarians to select the correct test for the dog in front of them.  

Multiple Genes, Similar Clinical Findings

The known underlying mutations associated with the various forms of PRA are found in a wide variety of different genes. Thus, highlighting the complexity of the biological pathways involved in the development and ongoing maintenance of the eyes. PRAs are marked by the abnormal development and/or the gradual degeneration of rod and cone photoreceptor cells of the retina. Each type of PRA may display variation in the age of onset, speed of disease progression, and the relative rates at which each of the two photoreceptor types are destroyed. However, when it comes to clinical ...

Every breed of dog comes with drawbacks that we must accept as owners. It could be their size, how much they shed, physical requirements or limitations, or even the likelihood of developing genetic disorders. Knowing what you’re getting into, before you get into it however, can save you thousands of dollars and tons of heartache.

While you might love the looks and personality of a specific breed, you have to be honest with yourself as to whether or not you are capable of providing the dog with its required maintenance and if they honestly fit into your lifestyle.

Perhaps the best example of this honest assessment that I’ve read can be found in an article by Dr. Patty Khuly entitled "This Veterinarian’s Love-Hate Relationship with French Bulldogs."

In the article, Khuly outlines why she loves the French bulldog so much – their personality, looks and cuddle-ability among them. She’s also honest about how she’s come to own several over the course of more than a decade – primarily, owners that couldn’t afford the upkeep on dogs with severe issues, including cleft palate, dermatological problems and an emergency c-sections.

Before you blame the high-cost of veterinary care ...