Tag archives: abnormal bleeding

Thrombopathia: A Preventable Inherited Disease of the Basset Hound

Thrombopathia: A Preventable Inherited Disease of the Basset Hound

Since the first exhibitions of the modern basset hound in the late 19th century, their mellow and charming personality has made them a popular family dog. Though according to the Basset Hound Club of America, it is not unusual for a basset hound to be a little stubborn or to have “selective hearing” (especially if following a scent trail), this minor annoyance is easily tempered by their affectionate and sensitive disposition. Originally bred for hunting with a person on foot, the basset hound’s short legs kept them from outrunning their handler while following their exceptional nose. Unfortunately, like other purebred dogs, the basset hound has also been unable to outrun susceptibility to certain inherited diseases. One such condition is a disease of blood platelets known as thrombopathia that occurs due to a mutation in the RASGRP1 gene.

Dogs affected with thrombopathia produce a dysfunctional form of a protein important in the aggregation of platelets during blood clotting. The resulting inability to produce functional blood clots leads to easy bruising and frequent episodes of spontaneous bleeding from the gums, nose, and the gastrointestinal tract. Affected dogs may also show signs of lameness due to spontaneous bleeding in joints. Loss of ...

My Dog’s Mouth Has Been Bleeding? What Could Be Wrong?

My Dog’s Mouth Has Been Bleeding?  What Could Be Wrong?

In my years as an undergraduate college student, struggling to make ends meet, I lived next door to a woman with an old, Labrador mix named Bubba.  By initial impression, he seemed to be a very normal, happy and well-socialized dog.  However, one day, during my daily greeting from Bubba, I noticed some blood around his mouth.  At the time, I was a biology major trying to wade through prerequisites for admission to veterinary school and I hadn’t yet been exposed to the world of clinical veterinary medicine.  So, when I saw the blood around Bubba’s mouth, I didn’t pay much attention.  I had seen blood in my own dog’s mouth on occasion after chewing on a toy or a bone and it never amounted to much.  So, my uninformed mind had little to worry itself about.  I later learned from Bubba’s owner that he had bled like this since he was young.  However, the owner had never taken Bubba to a veterinarian for a diagnosis and to this day I still don’t know what was wrong with him.  Though the memory of Bubba had ...