The Paw Print Genetics Blog

Paw Print Genetics, a Family Endeavor

Paw Print Genetics, a Family Endeavor

Paw Print Genetics is a clinical laboratory dedicated to screening and diagnosis of genetic diseases and carrier states for all dogs. In deciding to start my second company, I engaged the help of my family members. My husband needed to be agreeable to investing (emotionally and financially) in another (yes, another) clinical laboratory. But this time, it would be ours and we could make the decisions, good or bad; we would be responsible for its successes and possible failures. After convincing him that Paw Print Genetics is a great idea, we started doing our homework. It is important to know the market. Our market is dog lovers; not a small market. They include owners, breeders, trainers, veterinarians and all the dogs that they breed, train and sell. Every dog deserves optimal genetic health.

Next came the science. Our staff spent months identifying the known genetic mutations in dogs and developing tests to accurately identify whether a dog is normal, a carrier or affected with these diseases. Some may ask “What does a human geneticist know about canine genetics?” Compared to the human medical literature, I was surprised how little is known about canine genetic diseases. The opportunities to make a ...

How does that work?

How does that work?

Another non-intuitive but common behavior of genes is that one gene can have different but apparently unrelated effects. This is somewhat the opposite of different genes having the same effect (discussed in my previous blog). Making it even more confusing, the same condition could have both at work!

One gene may create a specific appearance but can also cause issues that would not necessarily appear to be related. In scientific terms the word pleiotropy is used to refer to the phenomenon "when one allele or pair of alleles has different effects - particularly when these effects appear unrelated."

Many examples of this phenomenon exist in the dog world. With on-going research, more will no-doubt be identified.

The gene causing Merle color pattern increases the chance for deafness and eye defects. Certain "white" dogs also have increased risk of deafness related to being white. In other breeds, very white appearing dogs (due to other genes) and dogs with albinism have no associated risk for hearing loss. In the case of the Merle and "white piebald" associations the effect begins on cells derived from the neural crest affecting both pigment, auditory and potentially other neural-derived cells, but not all Merles, double merles and ...

Popular Sire Syndrome: When Winning Results in Losing

Popular Sire Syndrome: When Winning Results in Losing

A phenomenon in canine competition circles known as popular sire syndrome can produce strong, competitive and intelligent puppies that go on to become, and produce, champions. The occurrence can also produce puppies that fill the breeding pool with genetic maladies.

When a male dog wins a prestigious championship, he obviously has what it takes to win at the highest levels. The effect is that his value as a stud dog skyrockets as breeders with females hope to produce puppies that can replicate their father’s accomplishments.

Often that trendy stud dog is bred with many female dogs throughout the country. When this happens, you can see that male dog show up in pedigrees from previously unrelated lines. In a large breeding pool, say with Labradors, the effects aren’t as profound as in a smaller population, but they’re still present and can cause issues for future generations regardless of population size. If that popular stud dog has any genetic disorders in his DNA, his puppies will likely harbor those mutations – at best becoming carriers and at worst being affected with the related disorder – and can continue to contaminate the breeding pool.

Even in a large breeding population, the bottleneck ...

So what is it? Dominant, Recessive, not genetic at all?

So what is it?  Dominant, Recessive, not genetic at all?

One of the key issues that people often have in grappling with genetics disease is the fact that genes and disorders that are supposedly genetic don't always make sense (or at least not the sense that people expect them to make.) What they see occur does not pass their intuition or logic of what they think they should see if the condition is really "genetic."

A problem will be identified that has never occurred before and people will say in all honesty---"that has never happened in my line" and yet they are told it is "genetic." This happens in human families as well. A genetic condition is diagnosed in a child and the first thing that both grandmothers say is "that did not come from our side of the family!" In some cases they may be wrong and in others they may be right. Different genes follow different "rules."

Recessive disorders in fact come from both families and are due simply to the fact that both the sire and dam happened to carry the same detrimental recessive gene. These can be passed on for many generations unrecognized and only revealed when two carriers happen to mate AND both ...

A Mother’s Genetic Influence and Health Count

A Mother’s Genetic Influence and Health Count

There’s a saying in dog breeding: "like produces like." A good breeder knows this and will attempt to pair dogs similar in conformation, drive, disposition and trainability together so the puppies will be of consistent and known quality.

When it comes to selecting a puppy that is to be used for a very specific task, such as hunting, the show ring, herding or guide and detection dogs, future successes and ease of training for those tasks are heavily dependent genetics. Finding the best line of dogs with proven genetics, as well as the disposition and conformation you want is most greatly influenced by the dog’s sire and dam.

Too often today it seems that an inordinate amount of emphasis is placed on the sire’s accomplishments and lineage. While selecting a sire with a pedigree decorated with titles, or one with comprehensive experience, from the venue you’re wanting to participate in is important, the dam’s genetics, disposition and pedigree are just as important, if not more so.

There’s a theory out there, one that I like to keep in mind when looking at pedigrees, which says the bottom line of a dam’s pedigree is ...

Does your Dachshund sleep too much?

Does your Dachshund sleep too much?

Maybe your Doxie has Narcolepsy. Narcolepsy is an inherited condition known to affect Dachshunds. Narcolepsy is a disorder that affects a dog’s ability to stay awake for an extended period of time. Dogs with the inherited form of narcolepsy typically show signs of the disorder between one to six months of age. Affected dogs will fall asleep faster than normal dogs and appear sleepy more frequently. Episodes of narcolepsy tend to occur with positive stimulation like play or food. The affected dog may appear to collapse to the ground with a sudden loss of muscle tone but does not typically lose awareness. Symptoms do not progress over time and do not have other associated health problems.
Genetic testing of the HCRTR2 gene in Dachshunds will reliably determine whether a dog is affected with narcolepsy. Because narcolepsy is inherited in an autosomal recessive manner, the breeding of two carrier dogs has a 25% risk of producing affected pups. Testing is available from Paw Print Genetics to determine the genetic status of your Dachshund. It is recommended that carriers with this mutation are not bred to avoid affected pups.

Why do we do this?

Why do we do this?

Why? For the love of dogs. There is nothing more heartbreaking than when a dog that is loved and has been invested in dies. This is heart breaking when that dog has lived a long full life beyond the expectancy for his size and breed and when that dog has fulfilled many hopes and dreams planned for them. It is far more devastating when that loss is premature due to genetic disease. It is devastating when a much anticipated and planned for litter results in a puppy or puppies that die at a day or weeks old. It is worse still when serious problems occur at a year or two years of age, when that puppy is already a part of their owners' life, plans or family. Whether a beloved companion, part of the family, a beautiful show prospect full of potential, a working dog where hours upon hours have been spent in developing their inborn skills to serve an important purpose, or a performance dog trained to (or not quite to) perfection (as the case may be for many of us) it is tragic when this time, energy, love, hope, money, potential is dashed due to premature death or ...

Does your Brittany have recurring infections?

Does your Brittany have recurring infections?

Complement is a type of protein that plays an important role in the body’s immune system by attacking invading organisms such as bacteria. Complement 3 (C3) deficiency is a disorder of the immune system that affects the Brittany hunting dog. In this disorder, the complement protein is absent. Dogs with C3 deficiency may present with pneumonia and other reoccurring infections, excessive thirst and urination, weight loss, loss of appetite, mouth ulcers and depression. C3 deficient dogs may also develop kidney disease which can lead to kidney failure and death. Genetic testing of the C3 gene PRIOR to breeding in Brittany dogs will reliably determine whether a dog is a carrier of C3 deficiency. Carriers do not have any features of the disease but when bred with another dog that also is a carrier, there is a 25% risk to have affected pups. If the breeding pair has not been screened, prospective buyers should have the puppy screened PRIOR to purchasing to avoid this devastating disease. Paw Print Genetics can help you avoid this disease in your puppies and eliminate this gene from your breeding program.

Genetic mutation may make your Old English Sheepdog sterile

Genetic mutation may make your Old English Sheepdog sterile

Cilia are found on the surface of a large number of cells and beat together in waves to move objects, such as to remove particles and mucus from the windpipe and lungs. In this manner, cilia protect the respiratory system from pathogens that can lead to infection. The structures that make-up the cilia are also found in the flagellum or tails of sperm. Primary ciliary dyskinesia (PCD) is an inherited disorder of the cilia that can be found in the Old English Sheepdog. In PCD, affected dogs have cilia that do not function properly. Fluids cannot be moved in the respiratory tract and can lead to infection. Symptoms include coughing, sneezing, nasal discharge and frequent respiratory infections. Affected dogs may be sterile due to the inability of the sperm to swim properly. Genetic testing of the CCDC39 gene can reliably determine whether a dog is a genetic carrier of primary ciliary dyskinesia (PCD). Carrier dogs do not have features of the disease but when bred with another dog that also is a carrier, there is a 25% risk of having affected pups. Testing should be done PRIOR to breeding so that carriers of this disease are not bred together. Screening ...

Genetic screening in Labradors: Pyruvate Kinase deficiency

Genetic screening in Labradors: Pyruvate Kinase deficiency

Labrador Retrievers are the most popular breed in the U.S. and in addition to making great pets, are commonly used as working dogs for hunting, seeing-eye dogs, and therapy dogs. Labradors carry a particularly large burden of genetic diseases, including diseases that can affect young pups. One such disease is Pyruvate Kinase Deficiency of the red blood cells (PKD). Symptoms may present as early as 2 to 3 months of age, presenting after the puppy has been purchased and delivered to their new owners.

Affected dogs have a hemolytic anemic that results in fewer red blood cells. The affected dogs tend to be smaller and weaker than their littermates. Other symptoms include exercise intolerance, pale mucous membranes, fast heart rate and heart murmurs. Enlargement of the spleen and liver is usually present by a year of age, and bone marrow and liver failure may occur by 5 years of age. Bone marrow transplant has been successful in treating the symptoms in affected dogs, although the cost prohibits this treatment in most affected dogs.

Genetic testing of the PKLR gene in Labrador Retrievers is available. Because this disease is inherited in a recessive manner, the mating pair may be carriers ...