Blog Archives for the year 2016

The Von Willebrand Disease Type II Mutation and the Boykin Spaniel

The Von Willebrand Disease Type II Mutation and the Boykin Spaniel

Von Willebrand disease (vWD) is a group of relatively common, inherited disorders of blood clotting in dogs. First described in humans in the 1920’s, vWD is now known to be caused by various mutations in the vWF gene which serves as a blueprint for a protein known as von Willebrand factor (vWF). The vWF protein plays an important role in the cessation of bleeding by binding and adhering platelets to wound sites. VWD is categorized into three main classifications (I, II, and III) based upon the quantity and structure of vWF protein present in affected dogs.

In 2004, a scientific paper was published by Kramer and others which described a specific mutation in the canine VWF gene associated with vWD in the German shorthaired pointer (around the same time, the same mutation was also identified as a cause of excessive bleeding in the German wirehaired pointer). Classified by clinical presentation as von Willebrand disease type II (vWDII), the discovered vWDII mutation has only been described in the scientific literature for the two German pointer breeds. However, the Paw Print Genetics laboratory identified the same mutation in several other breeds including the Boykin Spaniel. To our surprise, the mutation has been ...

Start Preparing for those Spring Babies Now

Start Preparing for those Spring Babies Now

Do you have an upcoming litter? Have you thought about the genetic testing that you will need?  It is important to plan ahead to save time and money, but also to ensure that you get results in time for sending your puppies off to their new home, each with a Canine Genetic Health CertificateTM.

By testing your dams and sires before they are bred, you will be able to avoid genetic disease in your puppies. As you plan your breeding, you can select to breed any carriers for a particular disease to a clear (normal) dog for that same disease. Although you are likely to produce carriers, for recessive conditions you will not produce pups at-risk for these diseases.  Now that your dams and sires have been fully tested with a Paw Print Genetics breed-specific panel, you are in great shape to select Mr. Right for each of your dams.

After carefully selecting your breeding pair, you now know what disease mutations your pups might carry.  This is when you should start planning genetic testing for your new litters. Paw Print Genetics has litter discounts every day to help you save money while being a responsible ...

Integrating Genetic Testing Into Veterinary Practice- Breeding Dogs

Integrating Genetic Testing Into Veterinary Practice- Breeding Dogs

Most veterinarians are well aware that canine hip and elbow radiographs, echocardiograms, and eye examinations have become routine veterinary health clearances requested by dog breeders. The goal of these diagnostics is to help breeders to improve their blood lines and produce healthy puppies. However, unless you work in a practice with a heavy canine reproduction case load, it is likely that you are less familiar with the genetic testing employed by breeders, what genetic tests are available, and how the results of genetic testing can help your dog-breeding clients attain their goals. Now that genetic testing has become a common addition to other pre-breeding canine health testing, gaining an understanding of available genetic testing and offering a service to help your clients complete their genetic testing through Paw Print Genetics (PPG), may increase the value of your customer relationships and build client loyalty, while at the same time, fulfilling your veterinary goal to improve the quality and length of puppies’ lives. How often do you discuss genetic testing with your dog breeder clients?

Dog Breeding and Genetic Testing

Though vet school curriculums have historically addressed canine inherited diseases and treatments for these conditions, much less emphasis has been placed on ...